Alzheimer’s Disease, a progressive neurological disorder, has been increasingly linked to inflammation. This article, based on the study by Sinyor, Mineo, and Ochner (2020), explores the intricate relationship between inflammation, oxidative stress, and Alzheimer’s Disease, highlighting the potential of antioxidants in disease management.
Inflammation and Alzheimer’s Disease
Alzheimer’s Disease’s pathogenesis is multifaceted, with inflammation playing a critical role. Pro-inflammatory cytokines, such as TNF-α, IL-1β, and IL-6, are elevated in Alzheimer’s Disease, contributing to amyloid-beta (Aβ) plaque aggregation and tau hyperphosphorylation, leading to neuronal loss. The brain’s immune cells, like microglia and astrocytes, become dysregulated, further exacerbating inflammation and Alzheimer’s Disease progression.
Antioxidants as a Therapeutic Strategy
Antioxidants like vitamin E and C, known for combating oxidative stress, offer a therapeutic avenue in Alzheimer’s Disease. Vitamin E, especially in its α-tocopherol form, has shown promise in mitigating Alzheimer’s Disease’s progression, potentially due to its antioxidant properties and ability to inhibit neuronal death caused by inflammatory processes.
Conclusion
Understanding inflammation’s role in Alzheimer’s Disease opens up potential pathways for treatment, emphasizing the importance of antioxidants. While current research provides foundational knowledge, further studies are essential for developing targeted, effective therapies for Alzheimer’s Disease.
Reference
Sinyor, B., Mineo, J., & Ochner, C. (2020). Alzheimer’s Disease, Inflammation, and the Role of Antioxidants. Journal of Alzheimer’s Disease Reports, 4(2020), 175-183. DOI: 10.3233/ADR-200171.
